miércoles, 21 de octubre de 2009

118 METABOLISMO DE AMINOACIDOS Y PROTEINAS


CONTENTS: METABOLISM OF AMINO ACIDS AND PROTEIN
GENERAL PURPOSE: Upon completion of this unit, the student will describe the most important processes in the metabolism of nitrogenous compounds.
OBJECTIVES:
1. Identify sources of amino acids
2. identify the essential and nonessential amino acids
3. Describe three mechanisms used by humans for you to remove nitrogen from metabolism of amino acids before their carbon skeletons.
4. Describe the reactions of transamination and mining work, identifying the subcellular localization, substrates, enzymes and products of the activity of these enzymes.
5. Describe the role of vitamin B6 and the reactions of aminotransferases.
6. Identify the role of glutamine and glutamic acid in the metabolism of nitrogen compounds. Describe the role of glutamine synthetase, glutamate dehydrogenase, transaminase and glutamine in the metabolism of nitrogen compounds.
7. Pinpoint the causes of the toxicity of ammonium ion and the body mechanisms to combat it.
8. Describe the process of synthesis of urea, indicating the subcellular localization, substrates, enzymes and pathway products.
9. Describe the regulation of urea synthesis and metabolism defects that cause alterations in this process, indicating its physiological consequences.
10. Summarize the sequence of reactions of urea and trace the flow of nitrogen from amino acids into and out of the cycle.
11. Define terms and give examples of other ketogenic and glucogenic amino acid.
12. Identify the amino acid precursors α-ketoglutarate, pyruvate, acetoacetate, fumarate and oxaloacetate.
13. Summarize the Factors Contributing to the entry and exit of the free amino acid pool in animals.
14. Explain the metabolic basis of the following inborn errors of metabolism: Propionic acidemia, Methylmalonic acidemia, hipervalinemia, phenylketonuria and alkaptonuria.
15. Explain the Therapeutic fenilcetunuria and maple syrup urine disease.
REFERENCES: I, IV, V, VII, http://www.uky.edu/~dhild/biochem/24/lect24.htmlVIIIhttp://www.systemsbiology.org/Technology/Data_Visualization_and_Analysis/Human_Proteome_Folding_Project Bhttp://www.youtube.com/watch?v=aq0NVvONB4Q ACIDO GLUTAMICOhttp://www.youtube.com/watch?v=rX_WH1bq5HQPROTEINAShttp://www.youtube.com/watch?v=st_6Be5z9N8http://www.youtube.com/watch?v=sP9JAllZ-h0&feature=fvwhttp://www.youtube.com/watch?v=UtpFqrezOgY&feature=relatedhttp://www.youtube.com/watch?v=J2EDOx-EvI4&feature=relatedhttp://www.youtube.com/watch?v=ZmkEPuYQE8k&feature=relatedUREAhttp://www.youtube.com/watch?v=ZmkEPuYQE8k&feature=relatedhttp://www.youtube.com/watch?v=afUOVIFzA6c&feature=relatedhttp://www.youtube.com/watch?v=01y8nl3aWtE&feature=fvwhttp://www.youtube.com/watch?v=j71CdfQt3f8&feature=relatedChttp://www.youtube.com/watch?v=kXERVFvTioM&feature=relatedCATABOLISMO PROTEICOhttp://www.youtube.com/watch?v=21dZvt9qduE&feature=relatedENZIMAShttp://www.youtube.com/watch?v=4Y_CzzzutUE&feature=relatedPKUhttp://www.youtube.com/watch?v=KUJVujhHxPQhttp://www.youtube.com/watch?v=k87hUZZxyaI&feature=relatedhttp://www.youtube.com/watch?v=b9jyJGwnSuc&feature=relatedALKAPTONURIAhttp://www.youtube.com/watch?v=5B9KDcoRYr8&feature=relatedhttp://www.youtube.com/watch?v=kwuRFhW5aqw MAPLE SYRUM MAPLEhttp://www.youtube.com/watch?v=308yzwGEeYw&feature=relatedhttp://www.youtube.com/watch?v=nbT9MTii0zc&feature=relatedhttp://www.youtube.com/watch?v=1gb17JvTFKU&feature=relatedhttp://www.youtube.com/watch?v=SEHtPwsixFs&feature=relatedhttp://www.youtube.com/watch?v=cRQo93XZAgk&feature=relatedP450http://www.youtube.com/watch?v=1gb17JvTFKU&feature=relatedhttp://www.youtube.com/watch?v=D7CnwmZ9h8A&feature=relatedhttp://www.youtube.com/watch?v=inFqj4wumRA&feature=relatedAPOPTOSIS http://www.youtube.com/watch?v=l4D0YxGi5Ec&NR=1http://www.youtube.com/watch?v=YigXvbPkMCE&NR=1&feature=fvwphttp://www.youtube.com/watch?v=witLM--V2v8&NR=1http://www.youtube.com/watch?v=9KTDz-ZisZ0&feature=relatedhttp://www.youtube.com/watch?v=7O-fhxdq3Vo&feature=related

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